Expression and clinical significance of Bmi-1,Podoplanin and p53 in human thymic epithelial tumor
- VernacularTitle:Bmi-1、Podoplanin和p53在胸腺上皮肿瘤中的表达及意义
- Author:
jie, WU
;
gang, CHEN
- Publication Type:Journal Article
- Keywords:
Bmi-1;
Podoplanin;
p53;
thymic epithelial tumor;
immunohistochemistry;
tissue chip
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and clinical significance of Bmi-1,Podoplanin and p53 in human thymic epithelial tumor(TET) according to new histological classification of World Health Organization. Methods One hundred and ten TET tissue chips were prepared,and the expressions of Bmi-1,Podoplanin and p53 were detected by NovoLinkTM Polymer detection systems. Results The positive expressions of Bmi-1,Podoplanin and p53 were 68.2%,41.8% and 42.7%,respectively.The positive expressions of Bmi-1,Podoplanin and p53 were significantly associated with pathologic histological classification,Masaoka staging and clinic pathological grading(P
