Protective Effect of Erigeron Breviscapus(Vant.)Hand-Mazz on Retinal Ganglion Cells and Optic Nerve in Rabbits with Elevated Intraocular Pressure
- VernacularTitle:灯盏细辛对兔高眼压视网膜神经节细胞及视神经损伤的保护作用
- Author:
yi-sheng, ZHONG
;
min-hong, XIANG
;
wen, YE
- Publication Type:Journal Article
- Keywords:
Erigeron Breviscapus(Vant.)Hand-Mazz;
chronic elevated intraocular pressure;
retinal nerve fiber layer;
retinal ganglion cells;
optic nerve;
protective effect;
rabbit
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the protective effect of Erigeron Breviscapus(Vant.)Hand-Mazz(EBHM) on retinal ganglion cells(RGCs) and optic nerve in rabbits with elevated intraocular pressure(IOP). Methods Twenty rabbits with chronic elevated IOP were divided into two groups randomly: EBHM treated group(the ocular hypertension with EBHM treated subgroup and the normal IOP with EBHM treated subgroup) and untreated group(the simple ocular hypertension subgroup and the simple normal IOP subgroup). EBHM was irrigated into the stomachs to the treated group after IOP elevated continuously for 7 d.For light and electron microscopy studies,the rabbits' eyes were made into eyeball samples and optic nerve samples after 60 d.The density of RGCs,thickness of retinal nerve fiber layer(RNFL),and optic nerve axons were observed and quantitated by computer image analysis system.The ultra-microstructure changes of RGCs and optic nerve axons were observed by electron microscope.Results(①The RNFL) thickness,RGCs density and number of axons of the two ocular hypertension subgroups were decreased,compared with those of the two normal IOP subgroups(P
