Effect of hypothyroidism on oxidative stress status in developing rat brain
- VernacularTitle:甲状腺功能减退对发育期鼠脑氧化应激状态的影响
- Author:
hong-mei, ZHANG
;
qing, SU
;
min, LUO
- Publication Type:Journal Article
- Keywords:
hypothyroidism;
thyroid hormone;
oxidative stress;
brain development;
brain damage;
rat
- From:Journal of Shanghai Jiaotong University(Medical Science)
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of hypothyroidism on oxidative stress status in developing rat brain and to further explore the mechanism of impaired brain development caused by hypothyroidism. Methods Perinatal hypothyroidism was induced by administering propylthiouracil(PTU) solution to the dams by gavage.The oxidative stress indexes were measured in brain homogenate of normal and hypothyroid pups which were sacrificed on the 21st d after birth. Results As compared to the control,the following indexes were found to be increased in the hypothyroid group: protein carbonyl contents,thiobarbital acid reactive substances,reduced glutathione,total antioxidative capacity,activities of superoxide dismutase and glutathione peroxidase(P0.05). Conclusion Hypothyroidism during rat brain development may cause oxidative stress,which may be related to the brain damage caused by hypothyroidism.
