Relationships of Serum Leptin,Tumor Necrosis Factor-? and Insulin Resistance in Simple Obesity Children
- VernacularTitle:单纯性肥胖儿童血清胰岛素水平与瘦素、肿瘤坏死因子-?的关系
- Author:
min, GONG
;
jun-feng, LI
;
li-ming, SUN
;
jing-ning, HUANG
;
shou-kang, CHEN
;
jian-nian, JIN
- Publication Type:Journal Article
- Keywords:
obesity;
hyperinsulinism;
leptin;
tumor necrosis factor;
insulin resistance
- From:Journal of Applied Clinical Pediatrics
2004;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationships of serum leptin(LP),tumor necrosis factor-?(TNF-?)and insulin resistance in simple obesity children.Methods Forty-seven children with simple obesity were divided into two groups: high insulin group(HIG) and normal insulin group(NIG) according to the levels of fasting state of serum insulin and glucose.The fasting state of serum insulin(FINS),LP,TNF-? and fasting blood glucose(FBG) were measured.The relationships of LP,TNF-? and insulin resistance index(HOMA-IR) were also analyzed.Results 1.The BMI,waist,hip,waist hip ratio(WHR),LP,TNF-?,HOMA-IR were obviously higher in the HIG than those in the NIG and NCG groups(Pa0.05).3.In the HIG group,the FINS was positively correlated to LP,TNF-? and HOMA-IR(r=0.560,0.413,0.864 P
