Study on Drug Resistance Inversed by Quercetin in K562 and K562/ADM
- VernacularTitle:槲皮素逆转K562、K562/ADM细胞耐药性研究
- Author:
lu-lu, HE
;
ren-yi, FU
;
yi-ping, ZHU
;
qiang, LI
;
xuezhen, WU
- Publication Type:Journal Article
- Keywords:
quercetin;
multidrug resistance;
leukemia
- From:Journal of Applied Clinical Pediatrics
2006;0(21):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of HSP70 mRNA or MDR1 mRNA by quercetin in leukemia.Methods Methyl thiazoly tetrazolium(MTT) asssy was used to detect the growth suppression of Quercetin on K562 cells.The expression of HSP70 mRNA and MDR1 mRNA were detected in ADM plus Quercetin,Quercetin plus ADM group.The 2 of them were detected in K562/ADM cells in Quercetin plus ADM group.Results 1.Quercetin could suppress the growth of K562 cells.2.The expression of HSP70 mRNA and MDR1 mRNA detected by reverse transcriptase-polymerase chain reaction(RT-PCR) decreased in K562 and K562/ADM cells in Quercetin plus ADM group compared with ADM group and control(P
