Protective Effects of Quercetin on Daunorubicin-Induced Cardiomyocyte Injury
- VernacularTitle:槲皮素对柔红霉素致大鼠心肌细胞损伤的保护作用
- Author:
lei, ZHOU
;
yong-hong, LAI
- Publication Type:Journal Article
- Keywords:
quercetin;
daunorubicin;
cardiomyocyte injury;
cytoprotection;
antioxidation
- From:Journal of Applied Clinical Pediatrics
2006;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effects of quercetin on primary cultured SD neonate rats cardiomyocyte injury induced by daunorubicin.Methods Cultured cardiomyocytes were divided into blank groups,DNR groups,DNR+QUE groups,QUE groups.After preincubation of cardiomyocytes for 24 hours,cytoprotection effect was assessed by cell morphous,and cell apoptotic rates determined by flow cytometry,extracellular lactate dehydrogenase(LDH),superoxide dismutase(SOD) and malondialdehyde(MDA).Results Compared with DNR groups,the shedded cardiomyocytes and the cell debris of DNR+QUE groups decreased;the cardiomyocyte apoptosis rates decreased;the content of LDH and MDA decreased(P
