Hepatoprotective Effects of Silybin-Phosphatidylcholine Complex in Septic Rats
- VernacularTitle:水飞蓟宾磷脂酰胆碱复合物对脓毒症幼鼠肝脏损伤的保护作用
- Author:
xing-xia, LIU
;
pei-yong, QIU
;
jian-zhi, GAO
;
zheng-yue, CHEN
- Publication Type:Journal Article
- Keywords:
silybin phosphatid-ylcholine complex;
sepsis;
interleukin-1;
alanine aminotransferase;
aspartate aminotransferase
- From:Journal of Applied Clinical Pediatrics
2004;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the hepatoprotective effect of silybin-phosphatidylcholine complex(SPC) in sepsis rats.Me-(thods) Fifty Wistar immature rats were randomly divided into 3 groups:normal control(10 cases),septic group(30 cases) and interfe-(rence) group(10 cases).In septic group and interference group,rats were treated by cecal ligation and puncture(CLP).Meanwhile,the interference group was given SPC before 2 hours of CLP and after 2 hours of CLP.Blood of rats was taken from all groups to determine the levels of serum tumor necrosis factor-?(TNF-?),interleukin-1(IL-1),alanine aminotransferase(ALT) and aspartate aminotransferase(AST) at varying intervals.Results The levels of serum TNF-?,IL-1,ALT and AST after CLP were significantly elevated in septic group compared with the normal control group(P
