Research progress of IGF-1R in ophthalmology
10.3760/cma.j.issn.2095-0160.2014.12.021
- VernacularTitle:胰岛素样生长因子1受体在眼科疾病中的研究进展
- Author:
Jianmei, LV
- Publication Type:Journal Article
- Keywords:
Insulin-like growth factor 1 receptor;
Choroid melanoma;
Thyroid associated opthalmopathy;
Macular degeneration;
Refractive error
- From:Chinese Journal of Experimental Ophthalmology
2014;32(12):1148-1152
- CountryChina
- Language:Chinese
-
Abstract:
Insulin-like growth factor 1 receptor (IGF-1 R),a member of the family of tyrosine protein kinase,mediates the activity of the IGF-1.IGF-1R can promote the proliferation and migration of cells and inhibit the apoptosis of cells.IGF-1R shows a high level expression and presents a close relationship with a variety of biological characteristics such as invasion and metastasis of choroid melanoma,and it influences the pathogenesis and progress of thyroid related ophthalmopathy,working together with thyroid stimulating hormone receptor (TSHR) through different signaling pathways.Also IGF-1 R,targeting vascular endothelial growth factor (VEGF),may promote the pathogenesis and development of new retinal vascular diseases through the insulin receptor substrate 1 (IRS-1).Other IGF-1R related biological effects were found in eye diseases,such as refractive error and cataract,ect.,hinting us that as a molecular targete,IGF-1R will become a new topic of gene therapy for eye diseases.
