Research progress of osteopontin and ocular neovascular diseases
10.3760/cma.j.issn.2095-0160.2014.12.019
- VernacularTitle:骨桥蛋白与眼部新生血管性疾病研究进展
- Author:
Meng, HU
- Publication Type:Journal Article
- Keywords:
Osteopontin;
Corneal neovascularization;
Choroidal neovascularization;
Retinal neovascularization
- From:Chinese Journal of Experimental Ophthalmology
2014;32(12):1140-1143
- CountryChina
- Language:Chinese
-
Abstract:
Ocular neovascularization is the primary cause of blindness in a wide range of ocular diseases.The common blinding diseases,including diabetic retinopathy,age-related macular degeneration,infectious keratitis,are all caused by neovascularization.Osteopontin (OPN) is a glycoprotein,which can promote angiogenesis and tissue repair.It is aboudantly expressed in corneal neovascularization,choroidal neovascularization and retinal neovascularization,and promotes angiogenesis.The relationship between OPN and ocular neovascularization provides a new direction in research and treatment of neovascular diseases.This paper reviewed the research progress of OPN and ocular neovascular diseases.
