Current study and progress in nuclear factor-E2-related factor 2 and ocular fundus disease
10.3760/cma.j.issn.2095-0160.2014.11.018
- VernacularTitle:核因子-E2相关因子2在眼底病中的研究现状与进展
- Author:
Sisi, WENG
- Publication Type:Journal Article
- Keywords:
Nuclear factor-E2-related factor 2;
Oxidative stress;
Ocular fundus disease
- From:Chinese Journal of Experimental Ophthalmology
2013;32(11):1048-1051
- CountryChina
- Language:Chinese
-
Abstract:
Nuclear factor-E2-related factor 2 (Nrf2) plays a critical role in the regulation of cellular redox status.It induces the expression of antioxidant enzymes and phase 2 by binding to the antioxidant response element (ARE) in the promoter region of the genes.Nrf2 may present anti-inflammation,immunodepression,antiapoptosis and neuroprotection effects when cell redox status is out of balance.It participates in the pathogenesis and development of many ocular fundus diseases,such as age-related macular degeneration,diabetic retinopathy and ischemic-hypoxic retinopathy.This review focuses on the current study and progress in Nrf2 and ocular fundus diseases.
