Matrix metalloproteinases/tissue inhibitors of metalloproteinase system and diabetic ocular complications
10.3760/cma.j.issn.2095-0160.2014.09.021
- VernacularTitle:基质金属蛋白酶/基质金属蛋白酶组织抑制剂系统与糖尿病眼部并发症
- Author:
Meixia, REN
- Publication Type:Journal Article
- Keywords:
Matrix metalloproteinase;
Tissue inhibitior of metalloproteinase;
Diabetic mellitus/complication;
Retinopathy;
Cataract;
Keratopathy
- From:
Chinese Journal of Experimental Ophthalmology
2014;32(9):860-864
- CountryChina
- Language:Chinese
-
Abstract:
The matrix metalloproteinases/tissue inhibitors of metalloproteinase (MMPs/TIMPs) system plays an important role in the degradation and remodel of the extracellular matrix (ECM).MMPs/TIMPs system is associated with ocular physiological process,such as ocular growth and development,etc.Also,MMPs/TIMPs system is involved in ocular pathological process including inflammation,wound healing,neoangiogenesis,tumor invasion and metastasis.MMPs/TIMPs system also participats in the formation of some ophthalmic diseases such as proliferative vitreoretinopathy (PVR),proliferative diabetic retinopathy (PDR),diabetic cataract,rhegmatogenous retinal detachment (RRD),retinoblastoma (RB),age-related macular degeneration (AMD),ocular trauma,and glaucoma.This review attempts to elaborate the biological characteristics of MMPs/TIMPs,and the current researches of MMPs/ TIMPs system in the diabetic ocular complications,focusing on diabetic retinopathy,cataract and keratopathy.
