Immunization and glaucoma
10.3760/cma.j.issn.2095-0160.2014.05.017
- VernacularTitle:免疫与青光眼
- Author:
Weiyi, LI
;
Ping, HUANG
- Publication Type:Journal Article
- Keywords:
Autoimmune disease/immunology;
Glaucoma/immunology;
Retinal ganglion cell/immunology;
Optic nerve disease/immunology;
Autoantigen/immunology
- From:Chinese Journal of Experimental Ophthalmology
2014;32(5):466-470
- CountryChina
- Language:Chinese
-
Abstract:
Glaucoma,the major cause of global irreversible blindness,is a chronic neurodegenerative disease of the optic nerve.Apoptosis of retinal ganglion cells (RGCs) and progressive loss of optic nerve axons results in structural and functional deficits in glaucoma patients.Growing evidence obtained from clinical and experimental studies over the last decade strongly suggests the involvement of the immune system in the neurodegenerative process of glaucoma.This review aims to provide a perspective on the complex interplay of cellular events during glaucomatous neurodegeneration that involves aberrances or dysfunctions of immune system,such as ocular immune privilege,glial activation response,T cell-mediated immune responses,autoantibody-mediated immune responses,complement fixation reaction and aging,oxidative stress.The complex interplay of cellular events amplify the primary injury process and contribute to disease progression by oxidative stress and immune response,ultimately lead to cell death with loss of RGCs.
