Relationship between vascular endothelial growth factor-B and ocular neovascularization disease
10.3760/cma.j.issn.2095-0160.2014.05.019
- VernacularTitle:血管内皮生长因子-B与眼部新生血管性疾病
- Author:
Huilei, MA
- Publication Type:Journal Article
- Keywords:
Vascular endothelial growth factor-B;
Neovascularization disease;
Treatment
- From:Chinese Journal of Experimental Ophthalmology
2014;32(5):476-480
- CountryChina
- Language:Chinese
-
Abstract:
Abnormal neovascularization can lead to a variety of eye diseases,and vascular endothelial growth factor(VEGF) plays an important role in the generation and development of neovascularization diseases.As a member of VEGF family,VEGF-B can regulate neovascularization by the effect of vascular survival and cell apoptosis,in order to inhibit the generation and development of neovascularizition,while it has an insignificant impact to angiogenesis and vascular permeability.Meanwhile,VEGF-B can protect cardiac and neuron.As a method of clearly effective to treat neovascularization disease,anti-VEGF attracts extensive attention.Because of the dual character of VEGF-B,we need more studies on the effect of treating ocular neovascularization disease by the drug of anti-VEGF-B.This review summarizes the role of VEGF-B in blood vessel,cell,neuron and cardiac of body and its application in the treatment of ocular neovascularization disease.
