A randomized controlled trial comparing the efficacy of 10% guava extract shampoo versus 2% ketoconazole shampoo and clobetasol 0.05% shampoo in the treatment of scalp seborrheic dermatitis.
- Author:
Sarmiento-Naagas Vanessa
;
Medel Ruth B.
;
Angeles Camille Vanessa B.
;
Ampil Isaac David
- Publication Type:Journal Article
- Keywords: Guava Extract
- MeSH: Human; Male; Aged; Middle Aged; Adult; Clobetasol; Dandruff; Dermatitis, Seborrheic; Ketoconazole; Pruritus; Psidium; Scalp; Skin; Treatment Outcome
- From: Journal of the Philippine Dermatological Society 2013;22(1):17-22
- CountryPhilippines
- Language:English
-
Abstract:
BACKGROUND: Seborrheic dermatitis is a common chronic, relapsing inflammatory skin condition occurring most often on the face, scalp and chest.
OBJECTIVE: To compare the efficacy and safety of 10% guava extract shampoo versus 2% ketoconazole shampoo and clobetasol 0.05% shampoo in the treatment of scalp seborrheic dermatitis.
METHODS: Forty-five patients clinically diagnosed with scalp seborrheic dermatitis were randomized to one of the three treatment groups: 10% guava extract shampoo, 2 % ketoconazole shampoo and 0.05% clobetasol shampoo. Patients were followed-up weekly for two weeks to assess the Seborrheic Area Severity Index (SASI) scores, pruritus score, patient's global assessment of improvement and adverse events.
RESULTS: After two weeks of treatment, there was no significant difference in the three groups in terms of the mean change in SASI scores (p= 0.46, ANOVA), pruritus scores and in the patient's global assessment of improvement, and frequency of adverse events.
CONCLUSION: 10% guava extract shampoo is a safe and effective alternative treatment for scalp seborrheic dermatitis.