The Effect of the Serum Cholesterol Level on the Clinicopathologic Characteristics of Prostate Cancer.
10.4111/kju.2008.49.2.127
- Author:
Wooseuk SUNG
1
;
Seung Hyun JEON
;
Sung Goo CHANG
Author Information
1. Department of Urology, School of Medicine, Kyung Hee University, Seoul, Korea. sgchang@khu.ac.kr
- Publication Type:Original Article
- Keywords:
Prostatic cancer;
Cholesterol;
Prostatectomy
- MeSH:
Cholesterol;
Humans;
Incidence;
Medical Records;
Neoplasm Grading;
Prostate;
Prostatectomy;
Prostatic Neoplasms;
Retrospective Studies
- From:Korean Journal of Urology
2008;49(2):127-133
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We assessed the relationship between the serum cholesterol level and the clinicopathologic characteristics of prostate cancer patients who had undergone a radical retropubic prostatectomy. MATERIALS AND METHODS: We enrolled 70 prostate cancer patients who had relevant data available for this study. All of the patients had their serum cholesterol level checked at least three times for a month preoperatively. We divided them into three groups according to: 1) a mean preoperative cholesterol level less than 180mg/dl, 2) between 180mg/dl and 200mg/dl, and 3) more than 200mg/dl. The serum cholesterol levels and other clinicopathologic characteristics were then compared and analyzed. The clinicopathologic findings included the pathologic T stage, Gleason score, prostate-specific antigen(PSA) and the other pathologic findings that included perineural invasion, vascular invasion, lymphatic invasion and capsular invasion. All the data was retrospectively collected from the patients' medical records. RESULTS: The mean cholesterol level was 181.1+/-4.1mg/dl. There was a statistically significant difference in the incidence of perineural invasion among these three groups according to the cholesterol level, with linear correlation(p=0.015). This correlation was more significant among the T2 patients or the patients with a total PSA value of 4ng/dl to 10ng/dl. Furthermore, the preoperative serum cholesterol level was significantly affected by the pathologic finding of perineural invasion(p=0.024, odd ratio=3.565). CONCLUSIONS: There was a direct correlation between the increase incidence of perineural invasion with the increased preoperative serum cholesterol level for prostate cancer patients who had undergone radical prostatectomy.
