Evaluation of methanol extract of Polygonum minus Huds. leaves for its hepatoprotective activity
- Author:
Parayil Varghese Christapher
;
Lok Sin Joe
;
Manoontri Tian
;
Tanusha Sethi Brij Mohan
;
Subramani Parasuraman
;
Fouad Saleih Resq Al-Suede
;
Vikneswaran Murugaiyah
- Publication Type:Journal Article
- Keywords:
Carbon tetrachloride;
paracetamol;
silymarin;
Polygonum minus;
hepatoprotective effect
- From:Malaysian Journal of Microbiology
2016;12(5):345-352
- CountryMalaysia
- Language:English
-
Abstract:
Aims: Hepatotoxicity is a serious health risk and treatment options are inadequate. Polygonum minus Huds. (Family:
Polygonaceae) is an antioxidant rich, commonly available plant in Malaysia and used in the Malay folk medicine. The
leaves are also considered as one of the salad plants and flavouring agent for food delicacies. The present study
evaluates the hepatoprotective activity of methanol extract of P. minus leaves on carbon tetrachloride (CCl4) and
paracetamol-induced hepatotoxicity in Sprague Dawley rats.
Methodology and results: Methanol extract of P. minus (MEPM) was prepared by maceration method. The standard
drug and MEPM treated groups of rats were administered with silymarin (50 mg/kg) or MEPM (200 mg/kg or 400 mg/kg),
respectively for 14 days in both experimental models. All the animals in the CCl4-induced model were administered CCl4
and paracetamol in the other model except to respective normal control group to induce liver toxicity. Estimation of body
weight and liver weight, biochemical parameters including total protein, aspartate aminotransferase, alanine
aminotransferase, alkaline phosphatase and total bilirubin levels and histopathological studies were conducted. The
MEPM was found to have significant hepatoprotective activity in rats with CCl4 and paracetamol-induced liver damage
as noted from the analysis of body weight, serum marker enzyme activity and histopathology.
Conclusion, significance and impact study: The MEPM possesses significant hepatoprotective activity while the
activity is increased with dose in both experimental models. Inclusion of P. minus leaves in the food may be
recommended as it may help to counteract different types of chemical-induced liver damage.
- Full text:P020170106320369335236.pdf
