Leigh syndrome: MRI findings in two children
- Author:
AL Kartikasalwah
;
LH Ngu
- Publication Type:Case Reports
- Keywords:
Leigh syndrome, MRI, SURF1, mitochondrial
- From:Biomedical Imaging and Intervention Journal
2010;6(1):1-4
- CountryMalaysia
- Language:English
-
Abstract:
Leigh syndrome is a progressive neurodegenerative disorder of childhood. The symmetrical necrotic lesions in the
basal ganglia and/or brainstem which appear as hyperintense lesions on T2-weighted MRI is characteristic and one of the essential diagnostic criteria. Recognising this MR imaging pattern in a child with neurological problems should prompt the clinician to investigate for Leigh syndrome. We present here two cases of Leigh syndrome due to different biochemical/genetic defects, and discuss the subtle differences in their MR neuroimaging features.
- Full text:W020150910591369152974.pdf
