Assessing the quality of studies on screening primary aldosteronism by using plasma aldosterone to renin activity ratio
10.3760/cma.j.issn.1674-6090.2009.03.013
- VernacularTitle:血浆醛固酮/肾素活性比值对筛选原发性醛固酮症价值的文献质量评价
- Author:
Xiaojing GUAN
;
Bo ZHOU
;
Jing FAN
;
Suhua ZHANG
;
Wenlong ZHAO
;
Huacong DENG
- Publication Type:Journal Article
- Keywords:
Primary aldosteronism;
Plasma aldosterone to renin activity ratio;
Systematic review;
Quality assessment of diagnostic accuracy studies;
Diagnostic test
- From:Journal of Endocrine Surgery
2009;3(3):180-183
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the quality of international studies on using aldosterone to renin activity ratio (ARR) to diagnose primary aldesteronism. Methods We searched the Cachrane Library (1962-2007.12), PubMed(1970-2007.12) ,VIP(1989-2007.12) ,Wan Fang database(1982-2007.12) ,CBMdisc(1978 -2007.12) systematically. Language was limited to Chinese and English. The Quality Assessment of Diagnostic Accuracy Studies(QUADAS) was used to assess the quality of induced diagnostic studies by two reviewers inde-pendently. Results Fourteen studies were included and assessed. We found that most of the studies were not met with QUADAS items. Nine studies didn't chose correct cases that included miscellaneous cases and confused ca-ses. Eight studies didn't describe internalized or exclusive references clearly. The gold standard in three studies could not discriminate whether the diagnosis of patients was confirmed or not. Thirteen studies did not use blind trial to compare the diagnostic test and the gold standard. Conclusions The studies using ARR to diagnose pri-mary aldesteronism should be improved in patients selection, the gold standard selection, comparison of blind trial and bias control.
