A preliminary study of mechanism of periodontitis and periodontal therapy influence in insulin resistance for obesity rats
10.3969/j.issn.1006-5725.2017.08.012
- VernacularTitle:牙周炎与牙周治疗对肥胖大鼠胰岛素抵抗作用的影响
- Author:
Qiaoxue CHAI
;
Sulan ZHONG
;
Jia NI
;
Lei ZHOU
;
Lei CHEN
;
Jincai ZHANG
- Keywords:
Periodontitis;
Obesity;
Periodontal treatment;
Insulin receptor substrates
- From:
The Journal of Practical Medicine
2017;33(8):1239-1243
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the mechanism of the experimental periodontitis and initial periodontal therapy on insulin resistance of obese rats associated with periodontitis.Methods Blood samples were collected from SD rats of obese group,periodontitis associated with obese group,periodontal therapy group and control group.Body index,data about insulin resistance and Observed pathological changes were calculated.Results Comparison of four groups:more severe insulin resistance and islet structural dysfunction was observed in obesity with periodontitis group than that of group with obesity alone.After periodontal therapy,inflammation and insulin resistance may be improved.Results from pathological specimens also supported this result.Conclusions The periodontitis with obesity can enhance the inflammatory state of obesity and cause the deterioration of insulin resistance.The initial periodontal treatment can relieve the inflammation of obesity with periodontitis and improve the resistance of insulin.It may be the reason of insulin resistance when obesity with periodontitis that the signaling pathways of IRS-1 and IRS-2 blocked,and PDX-1,GK,GLUT and other protein expression inhibited.
