Toxic effect of rapamycin in a young rat model of pentylenetetrazole-induced Kindling epilepsy
10.3969/j.issn.1002-0152.2017.06.007
- VernacularTitle:雷帕霉素对未成年癫痫模型大鼠的毒性作用
- Author:
Yunfeng MA
;
Xiangqing WANG
;
Xu ZHANG
;
Senyang LANG
- Keywords:
Rapamycin;
Epilepsy;
Anti-convulsion drug
- From:
Chinese Journal of Nervous and Mental Diseases
2017;43(6):352-355
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the effectiveness and safty of intraperitoneal injection of rapamycin on epileptogenesis in a rat model of pentylenetetrazole-induced kindling epilepsy. Method The Sprague Dawley rats at 6-8 weeks old were randomly divided into group PTZ+RAPA and group PTZ+NS. The body weight, mortality and seizures were recorded at 1, 4 and 6 weeks after treatment. Mossy fiber sprouting in the hippocampal CA3 area and DG area was examined by Tim staining. Results 1.The rats mortality was 22.9% in PTZ+RAPA and 10.4% in PTZ+NS. Weight alteration was statistically significant between PTZ+RAPA and PTZ+NS at the corresponding time points (P< 0.001); 3. The kindling rate was 66.7% in PTZ+RAPA and 58.3% in PTZ+NS at 6 weeks and the difference was statistical significant between these two groups (P>0.05). There was no statistical significance in the seizure scores be-tween PTZ+RAPA and PTZ+NS (P> 0.05). 4.The scores of mossy fiber sprouting in hippocampal CA3 and DG areas was higher in PTZ+NS than in PTZ+RAPA (P<0.05). Conclusion Rapamycin cannot reduce or curb epileptic seizures in young rats. It can obviously reduce the weight of the young SD rats which may be associated with its side effects.
