Research progress of Ghrelin and obesity,insulin resistance and type 2 diabetes mellitus
10.3969/j.issn.1006-6187.2017.07.020
- VernacularTitle:Ghrelin与肥胖、胰岛素抵抗和2型糖尿病的研究进展
- Author:
Yingdong SUN
;
Kai MA
- Keywords:
Ghrelin;
Insulin resistance;
Diabetes mellitus,type 2;
Obesity
- From:
Chinese Journal of Diabetes
2017;25(7):666-669
- CountryChina
- Language:Chinese
-
Abstract:
Ghrelin is a small active peptide secreted by gastric fundus cell. As an endogenous ligand of growth hormone receptor,it helps to promote growth hormone secretion,increase food intake and participate in energy metabolism. Recently,studies have indicated that Ghrelin,together with other peripheral signals,participate in the regulation of glucose and lipid metabolism. Insulin resistance (IR) is an important pathophysiological basis of the development of type 2 diabetes mellitus (T2DM),while obesity is the common risk factor of both IR and T2DM. It has been confirmed that Ghrelin has a close and complex connection with obesity and T2DM. Further study about Ghrelin may open up a new way to the diagnosis and treatment of obesity and T2DM.
