Expression of Advanced Glycation End Products in a Rat Model of Polycystic Ovarian Syndrome

VernacularTitle:晚期糖基化终末产物在多囊卵巢综合征大鼠模型中的表达
Author: Yannan ZHAO ; Hongxiang LIU ; Jianing HUO ; Xiaoxin MA
Keywords: polycystic ovarian syndrome; advanced glycation end products; rat
From: Journal of China Medical University 2017;46(5):388-391
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of advanced glycation end products(AGEs)in a rat model of polycystic ovarian syndrome (PCOS)induced by dehydroepiandrosterone. Methods The PCOS rat model was established using dehydroepiandrosterone . After confirming that the model rats were set up successfully,serum AGEs concentrations were measured using competitive ELISA and the expression of AGEs in the ovarian tissues of these rats was detected using immunohistochemistry. Results The serum AGEs level in the experimental group were signifi?cantly higher than that in the control group(P<0.05). Furthermore,AGEs expression were significantly higher in the experimental group than in the control group(P<0.01). Conclusion AGEs are highly expressed in the rat PCOS model,signifying their importance in the diagnosis and pathogenesis of PCOS.