Effect of compound glycyrrhizin combined with fexofenadine hydrochloride in the treatment of chronic urticaria and its influence on plasma histamine
10.3760/cma.j.issn.1008-6706.2017.15.029
- VernacularTitle:复方甘草酸苷联合非索非那定治疗慢性荨麻疹的疗效及对患者血浆组胺水平的影响
- Author:
Zhiqiang ZHANG
- Keywords:
Urticaria;
Histamine;
Compound glycyrrhizin;
Fexofenadine hydrochloride
- From:Chinese Journal of Primary Medicine and Pharmacy
2017;24(15):2359-2362
- CountryChina
- Language:Chinese
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Abstract:
Objective To investigate the effect of compound glycyrrhizin combined with fexofenadine hydrochloride in the treatment of chronic urticaria and its effect on plasma histamine.Methods 100 patients with chronic urticaria were selected as study objects,and they were divided into the control group(50 cases) and observation group(50 cases) according to the random number table method.The control group was treated with fexofenadine hydrochloride,while the observation group was treated with compound glycyrrhizin on the basis of the control group.The clinical effect and plasma histamine level were compared between the two groups.Results The effective rate of the observation group was 96.0%,which was significantly higher than 84.0% of the control group(χ2=7.951,P<0.05).After treatment,the plasma histamine content of the observation group was (2.38±0.26)ng/mL,which was lower than (3.10±0.29)ng/mL of the control group,and the difference between the two groups was statistically significant(t=6.084,P<0.05).Conclusion The compound glycyrrhizin combined with fexofenadine hydrochloride in the treatment of chronic urticaria can reduce the symptoms of the patients,reduce the number and size of the patients and effectively control the clinical symptoms of the patients.And it can effectively reduce the level of plasma histamine in patients with good clinical effect and application value,it is worth to be promoted in clinical.
