Neural mechanism and evaluation of decision-making function in obsessive-compulsive disorder
10.3969/j.issn.1674-8115.2017.07.029
- VernacularTitle:强迫症决策功能的神经机制和评估
- Author:
Yue ZHOU
;
Haiyan JIN
;
Bomin SUN
;
Chencheng ZHANG
;
Shikun ZHAN
- Keywords:
obsessive-compulsive disorder;
decision making;
orbitofrontal cortex;
Iowa Gambling Task;
Game of Dice Task
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2017;37(7):1042-1045
- CountryChina
- Language:Chinese
-
Abstract:
Obsessive-compulsive disorder (OCD) is a chronic,disabling,mental disorder,which has been linked to significant abnormalities in certain brain areas,including the orbital frontal cortex and the anterior cingulate cortex.Neuroimaging studies have also shown that brain areas related to the decision-making function include the orbital frontal cortex and the dorsal prefrontal lobes.Furthermore,the association between OCD and decision-making function has been consistently demonstrated from a neurobiological perspective.Clinically,impaired decision-making ability is commonly observed in OCD patients,and there is a correlation between OCD and abnormal decision function.Decision-making tasks are typically divided into two types,decision-making under risk and decision-making under ambiguity,with the former commonly evaluated using the Iowa Gambling Task (IGT) and the latter using the Game of Dice Task (GDT).In this article the neural mechanism and evaluation methods of decision making in OCD were reviewed.
