Comparison of the Effects of Saccharomyces boulardii Sachets and Bismuth Agent both Combined with Triple Therapy on Helicobacter pylori Eradication
10.3870/j.issn.1004-0781.2017.09.010
- VernacularTitle:布拉氏酵母菌散与铋剂分别联合三联疗法根除幽门螺杆菌的效果比较
- Author:
Xiuyun SUN
- Keywords:
Saccharomyces boulardii sachets;
Bismuth agent;
Triple therapy;
Helicobacter pylori
- From:
Herald of Medicine
2017;36(9):990-992
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the efficacy and safety of Saccharomyces boulardii sachets and bismuth in the treatment of chronic gastritis and duodenal ulcer patients with Helicobacter pylori (Hp)infection.Methods A total of 176 patients with chronic gastritis or duodenal ulcer with Hp infection were enrolled.Patients with chronic gastritis (n=116) were randomly divided into the treatment group (58 cases) and the control group (58 cases): treatment group received triple therapy(rabeprazole+amoxicillin +levofloxacin) and Saccharomyces boulardii sachets for 14 days;control group received triple therapy and colloidal bismuth pectin for 14 days.Patients with duodenal ulcer (n=60) were ulcer group,given with bismuth-containing quadruple therapy for 14 days,then rabeprazole for 14 days.All patients were tested for 13 C urea breath test four weeks after stopping treatment.Results One hundred and seventy cases completed the trial.Hp eradication rate was 84.5%in treatment group,87.9% in control group,and 90.0% in ulcer group (analysis by intent of treatment,ITT analysis).The difference between the three groups was not statistically significant(P>0.05).The incidence of adverse events was significantly lower in treatment group (10.3%)than in control group (20.7%)and ulcer group (21.7%)(P<0.05).Conclusion Quadruple therapy with Saccharomyces boulardii sachets can effectively eradicate Hp.It can reduce the occurrence of adverse reactions.
