A pilot study of the opposing effects of hyperinsulinemia and hyperandrogenenism on serum lipid profiles and bioactive lipids in women with polycystic ovary syndrome
10.3760/cma.j.issn.1000-6699.2017.08.004
- VernacularTitle:胰岛素和雄激素对多囊卵巢综合征患者血清脂质谱及活性脂质生成调节的初步研究
- Author:
Shengxian LI
;
Qianqian CHU
;
Jing MA
;
Yun SUN
;
Tao TAO
;
Rong HUANG
;
Yu LIAO
;
Jiang YUE
;
Jun ZHENG
;
Lihua WANG
;
Xinli XUE
;
Mingjiang ZHU
;
Xiaonan KANG
;
Huiyong YIN
;
Wei LIU
- Keywords:
Polycystic ovary syndrome;
Lipidomics;
Insulin resistance;
Hyperandrogenism;
Obesity
- From:Chinese Journal of Endocrinology and Metabolism
2017;33(8):644-650
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate serum lipid profiles in newly diagnosed patients with polycystic ovary syndrome (PCOS) using lipidomics and correlate these features with hyperinsulinemia and hyperandrogenism associated with PCOS and obesity. Methods 32 newly-diagnosed PCOS women and 34 controls were enrolled and divided into obese and lean subgroups according to the body mass index (BMI). Anthropometric, biochemical, and hormonal parameters were collected. Serum lipid profiles including phospholipids, free fatty acids (FFAs), and bioactive lipids were analyzed using GC-MS and LC-MS. Results PCOS patients, in particular, the obese ones with fatty liver, have abnormal phosphatidylcholine (PC)/lysophospholipid (LPC) metabolism. PC was increased (16∶0, 18∶0, 18∶1, 18∶2, and 20∶4), while LPC was decreased (16∶0, 18∶0, and 18∶1; all P<0.05). Serum polyunsaturated fatty acids (PUFAs), were decreased significantly, and the long chain saturated fatty acid was increased. We also found that insulin stimulated the metabolism of PUFAs, but the androgen inhibits the metabolism of PUFAs by measuring their metabolites. Conclusion PCOS patients have metabolic disorders of phospholipids and PUFAs. Insulin stimulated while androgen inhibited PUFAs metabolism.
