Expressions of p16INK4a protein in cervical lesion tissues of Mongolian patients and their significances
10.13481/j.1671-587x.20170227
- VernacularTitle:p16INK4a蛋白在蒙古族患者宫颈病变组织中的表达及其意义
- Author:
Xin QIANG
;
Wenyan HUO
;
Can YANG
;
Yanan FAN
;
Caiyun SHI
;
Haihua BAI
- Keywords:
cervical neoplasms;
INK4a gene;
p16INK4a;
cervical intraepithelial neoplasia;
chronic cervicitis;
uterine leiomyoma
- From:
Journal of Jilin University(Medicine Edition)
2017;43(2):353-355,后插2
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To detect the expressions of p16INK4a protein in the cervical lesion tissues of the Mongolian patients, and to explore the relationship between its expression and the occurrence and development of cervical cancer in the Mongolian patients.Methods:A total of 100 cases of paraffin sections of cervical cancer, cervical intraepithelial neoplasia(CIN),chronic cervicitis and uterine leiomyoma were divided into 25 cases of cervical cancer, 35 cases of CIN, 20 cases of chronic cervicitis, and 20 cases of uterine leiomyoma groups. The expressions of p16INK4a protein in different cervical tissues were detected by immunohistochemical SP method.Results:The positive rates of p16INK4a protern in cervical cancer, CIN, chronic cervicitis and uterine leiomyoma tissnes were 100.0%, 74.3%, 25.0%,and 10.0%, respectively.The results of K-W H rank sum test for multiple sample comparisons showed that the positive expression rate of p16INK4a protein in cervical cancer tissue was significantly higher than those in CIN, chronic cervicitis and uterine leiomyoma tissues(P<0.05).Conclusion:p16INK4a protein can be used as a indicator to screen the Mongolian patients with early cervical cancer.
