Role of STAT3 mediates cardioprotection of ischemic postconditioning

VernacularTitle:STAT3介导缺血后处理心肌保护作用的研究
Author: Cheng SHEN ; Jianming CHEN ; Yijie HU ; Yi SONG ; Ye YUAN ; Qianjin ZHONG
Publication Type:Journal Article
Keywords: ischemic postconditioning; myocardial reperfusion injury; STAT3 transcription factor; rats
From:Journal of Regional Anatomy and Operative Surgery 2013;(6):631-632,634
CountryChina
Language:Chinese
Abstract: Objective To research ischemic postconditioning on heart function after myocardial ischemia-reperfusion(I/R),and the protective mechanisms. Methods Thirty-two rats were divided into four groups:I/R group ( n = 8 ) , ischemic postconditioning group (n=8),myocardial ischemic postconditioning+ NSC-74859 (STAT3 inhibitor) group(n=8),and control group(n=8). Establish a model of rat to observe changes of the heart rate,LVSP,+dp/dtmax,-dp/dtmax,coronary flow and myocardial enzyme spectrum in each group un-der different conditions. Results Compared with ischemia-reperfusion group,heart rate of the reperfusion period,CK and LDH of coronary ef-fluent in the ischemic postconditioning group were obviously lower,while left ventricular systolic pressure,change of intraventricular pressure, and coronary effluent volume increased obviously. And after inhibition of STAT3 expression,this protective effect decreased significantly. Con-clusion Ischemic postconditioning can provide potent cardioprotective effect in which STAT3 mediates the cardioprotective effects.