Silent mating-type information regulator 2 homolog 1 (SIRT1) in Alzheimer’ s disease:an update on potential mechanisms
10.3969/j.issn.1001-1978.2016.08.002
- VernacularTitle:沉默信息调节因子2同源蛋白1（SIRT1）与阿尔茨海默病研究进展
- Author:
Shifen DONG
;
Shengwei ZHANG
;
Jianning SUN
- Publication Type:Journal Article
- Keywords:
Alzheimer’ s disease;
silent mating-type information regulator 2 homolog 1;
Akt/protein kinase B;
amyloid-βaggre-gation;
tau protein phosphorylation;
synaptic plasticity
- From:
Chinese Pharmacological Bulletin
2016;32(8):1041-1043,1044
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer ’ s disease ( AD ) is characterized by pro-gressive loss of memory and other cognitive functions .With re-cent discoveries , activation of silent mating-type information reg-ulator 2 homolog 1 ( SIRT1 ) could attenuate the cognitive dys-function of AD via reducing amyloid-βaggregation and tau pro-tein phosphorylation , inhibiting inflammatory reaction , and regu-lating synaptic plasticity .This review aims to highlight the in-volvement of these new discoveries of SIRT 1, and Akt/protein kinase B(PKB) signaling pathways, for their potential therapeu-tic effect against AD .
