Research progress of JAK/STAT signal transduction pathway and traditional Chinese medicine intervention in the treatment of ischemic stroke
10.3969/j.issn.1001-1978.2016.07.001
- VernacularTitle:JAK／STAT信号转导通路及中药干预在缺血性脑卒中的研究进展
- Author:
Zhihong YANG
;
Ya HU
;
Xiaobo SUN
- Publication Type:Journal Article
- Keywords:
ischemic stroke;
JAK/STAT signal transduction pathway;
negative feedback regulation;
neuronal apoptosis;
inter-vention effect;
Traditional Chinese medicine
- From:
Chinese Pharmacological Bulletin
2016;32(7):889-893,894
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic stroke, gravely affecting human health with its increasing incidence rate , is a common disease of old age . JAK/STAT way , a recently discovered signaling pathway , is not only widely involved in processes of cell growth ,differentiation, and apoptosis ,but also closely related to the pathophysiology of stroke.However,the pathway function and mechanism in ische-mic cerebral stroke has not yet been fully elucidated .We will review the role and mechanism of JAK/STAT signal transduction pathway in ischemic stroke ,and scientifically draw network chart between various related signal molecules in the process of ische-mic stroke neuropathy combining both domestic and foreign re-search reported in this paper , in order to better understand the pathological mechanism process of brain stroke , find new drugs for the treatment of cerebral ischemic diseases ,then provide more systematic scientific literature support .
