Intervention Effects of Pollen Typhae Total Flavone on INS-1 PancreaticβCells Damage Induced by Palmitic Acid

VernacularTitle:蒲黄总黄酮对棕榈酸诱导损伤INS-1胰岛β细胞的干预作用
Author: Xiaotao FENG ; Jia LIU ; Ning LIANG
Publication Type:Journal Article
Keywords: Pancreaticβcells; Pollen Typhae total flavone/pharmacology; Type 2 diabetes/TCD therapy; Cell culture; Cell viability
From: Journal of Guangzhou University of Traditional Chinese Medicine 2015;(5):899-902,913
CountryChina
Language:Chinese
Abstract: Objective To investigate the effects of Pollen Typhae total flavone (PTF) on INS-1 pancreaticβcell damage induced by palmitic acid ( PA) . Methods INS-1 pancreatic β cells were given long-term induction with PA to establish the impaired cell model, and then were intervened with PTF. Cell viability was determined by tetrazolium salt ( XTT) colorimetry. Results PA impaired the viabilities of INS-1 pancreatic β cells in concentration- and time-dependent manner, and PTF improved the impairment of INS-1 pancreatic β cells induced by PA in concentration -dependent manner. Moreover, PTF showed better improvement on the impairment when the INS-1 pancreatic β cells were impaired more seriously by PA. Conclusion PTF has effects on ameliorating the impairment of INS-1 pancreaticβcells induced by PA for long time.