The clinical curative effect of labetalol in treatment of pregnancy hypertension and the influence on the out-come of delivery
10.3760/cma.j.issn.1008-6706.2016.03.002
- VernacularTitle:拉贝洛尔治疗妊娠期高血压疾病临床疗效及对分娩结局的影响
- Author:
Bin LI
- Publication Type:Journal Article
- Keywords:
Hypertension,Pregnancy-Induced;
Labor,Obstetric;
Labetalol
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(3):325-327,328
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effect of labetalol in treatment of pregnancy hypertension and the influence on the outcome of delivery.Methods 110 patients with pregnancy hypertension from July 2013 to July 2015 in Boai Hospital were selected as the research subjects,and they were randomly divided into observation group and control group,55 cases in each group.The control group was treated with conventional treatment,while the observation group was given labetalol on the basis of the control group.The clinical curative effect,birth outcomes were compared between the two groups.Results (1)After treatment,the diastolic blood pressure and systolic pressure in the observation group were (67.95 ±4.87)mmHg and (134.62 ±11.82)mmHg,which were lower than pre -treat-ment,the differences were statistically significant (t =7.435,9.224,all P <0.05).Those in the control group after treatment were (91.22 ±3.52)mmHg and (151.69 ±14.68)mmHg,which were significantly lower than before treat-ment (t =4.109,5.240,all P <0.05),the differences between the two groups after treatment were statistically signif-icant (P <0.05).(2)Neonatal Apgar score of the observation group was (9.33 ±0.76)points,which was signifi-cantly higher than (7.85 ±0.85)of the control group,the difference was statistically significant(t =5.108,P <0.05).The incidence rates of cesarean section,neonatal asphyxia,fetal distress and postpartum hemorrhage of the ob-servation group were 43.64%,3.64%,5.45%,3.64%,which were significantly lower than the control group,the differences were statistically significant (χ2 =8.942,19.057,14.122,16.936,all P <0.05).Conclusion The use of labetalol in treatment of patients with hypertension of pregnancy can significantly reduce the blood pressure level and birth's score,improve maternal birth outcomes,which is worth clinical promotion.
