Neuroprotective effect of sulfated pachymaran on the MPTP-induced Parkinson mice

VernacularTitle:硫酸化茯苓多糖对 MPTP 诱导帕金森小鼠的神经保护作用研究
Author: Guizhen GAO ; Junbo WANG ; Fang JIANG ; Guangkun LI ; Xiaoyang LIU ; Hongyu XUE
Publication Type:Journal Article
Keywords: sulfated pachymaran; Parkinson mouse model; MPTP; SOD; GSH-Px; CAT
From: Chinese Pharmacological Bulletin 2015;(12):1699-1703,1704
CountryChina
Language:Chinese
Abstract: Aim To determine the neuroprotective effect of sulfated pachymaran (SP)on MPTP-induced
mouse model.Method ICR mice were randomly di-vided into control group,MPTP group and SP treatment group (50,1 00,1 50 mg·kg -1 ,ip).After 1 7 days, the activities of endogenous antioxidants (SOD,GSH-Px,CAT),antisuperoxide anion,hydrogen peroxide and MDA content in the midbrain and cortex were as-sayed.Results The results proved that SP significant-ly reduced the content of MDA and H2 O2 ,regulated
the activities of antioxidant enzyme and increased the activity of antisuperoxide anion.Conclusion All these effects indicate that SP is a potential neuroprotective a-gent and its neuroprotective effects are achieved in the MPTP mouse model.