Association between ADRB2 rs1042713 gene polymorphism and susceptibility of asthma in Chinese Population:a meta-analysis
10.3969/j.issn.1000-484X.2015.08.007
- VernacularTitle:ADRB2基因rs1042713位点多态性与中国人群哮喘易感性关系的荟萃分析
- Author:
Jinglin CHEN
;
Xiang HUANG
;
Jiayu TAN
;
Zhidan WAN
;
Xuewei WU
;
Dongxiu LI
- Publication Type:Journal Article
- Keywords:
ADRB2;
Genetic polymorphism;
Asthma;
Meta-analysis
- From:
Chinese Journal of Immunology
2015;(8):1037-1039,1048
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association between rs1042713 polymorphisms of ADRB2 gene and the susceptibility of asthma in Chinese Population by meta-analysis.Methods: The Pubmed database,Emabase database,Web of Knowledge database, CNKI database,Wanfang database and Weipu database were searched for all publications about the susceptibility of asthma and the rs1042713 polymorphisms of ADRB2 gene in Chinese Population.The article which met the inclusion criteria were assessed by the STA-TA12.0 software.Results:12 studies were included,with 2 193 asthmatic patients and 2 033 controls.All the included articles were satisfied to the Hardy-Weinberg equilibrium.The results of Meta-analysis was showed that the risk of asthma of the mutations G carriers ( GG +GA) on ADRB2 gene rs1042713 loci in Chinese people compared with the wild-type homozygotes( AA) was not significantly in-creased overall(OR=1.08,95% CI=0.82-1.44).However,subgroup analysis showed that the risk of G carriers of children had a relatively higher incidence(OR=1.69,95% CI 0.99-2.87),while the risk of adult-onset have a relatively lower incidence(OR=0.88,95%CI 0.68-1.15).Conclusion:The ADRB2 gene rs1042713 polymorphisms have a certain correlation with the susceptibility of asthma in Chinese children,the mutant gene G carriers may relatively increase the risk of asthma in childhood.
