Local injection of Icariin on orthodontically induced inflammatory root resorption in rats

VernacularTitle:局部注射淫羊藿苷对大鼠正畸致炎性牙根吸收的影响
Author: Yanni ZHOU ; Xueshun YUAN ; Ziqi YUE ; Baocheng CAO
Publication Type:Journal Article
Keywords: Icariin; orthodontically induced inflammatory root resorption; local administration; resorption pit
From: Journal of Xi'an Jiaotong University(Medical Sciences) 2015;(3):400-403,413
CountryChina
Language:Chinese
Abstract: Objective To study the influence of local administration of Icariin on orthodontically induced inflammatory root resorption (OIIRR ).Methods After rat models of orthodontic root movement were successfully established,rats were injected with 200 mg/kg Icariin (Icariin group)or saline (positive control group), respectively.Left maxillary served as the negative control group.The resorption pit of root surface was measured using scanning electron microscopy (SEM), HE staining, and tartrate resistant acid phosphatase (TRAP ). Results The level of TRAP positive cells and root resorption score in Icariin group were significantly lower than those in the positive control group (P < 0.05 ).Each measured value differed significantly between thenegative control group and the positive control group (P <0.05).The level of TRAP positive cells was significantly different (P <0.05),while root resorption scores did not differ between Icariin group and the negative control group (P >0.05).Conclusion Local administration of Icariin may reduce the degree of orthodontically induced resorption.