Effects of Gastrodin on BDNF Expression in AD Tree Shrew
- VernacularTitle:天麻素对老年痴呆树鼩海马BDNF表达的影响
- Author:
Baoli HE
;
Jianlin JIAO
;
Bo LI
;
Jintao LI
;
Limei WANG
- Publication Type:Journal Article
- Keywords:
Tree shrew;
Alzheimer's disease;
Gastrodin;
BDNF expression
- From:
Journal of Kunming Medical University
2013;(9):29-30,37
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of gastrodin on brain-derived neurotrophic factor (BDNF) expression in Alzheimer's disease ( AD) tree shrew. Methods AD tree shrew model was established by intracerebroventricular injection with amyloid-βpeptide (Aβ) . Since the eighth day after injection, the tree shrews were treated with gastrodin for thirty days. The expression of BDNF in tree threw hippocampus was detected by reverse transcription polymerase chain reaction (RT-PCR) . Results The expression of BDNF mRNA in the treatment group was higher than that in the model group ( <0.05) . Conclusion Gastrodin can increase some degree of the expression of BDNF.
