Expression of Bcl-w in gastric carcinoma and associated clinicopathologic factors

VernacularTitle:Bcl-w基因在胃癌中的表达和临床病理因素的关系
Author: Zhanwei HAO ; Deqing JIANG ; Chunxian XIA
Publication Type:Journal Article
Keywords: Stomach neoplasms; Bcl-w; MMP-2; Prognosis
From: International Journal of Surgery 2011;38(7):458-461,505
CountryChina
Language:Chinese
Abstract: Objective To discuss the meaning and association with prognosis of Bcl-w expression in gastric carcinoma. Methods By Immunohistochemistry( SP) method was used to detect the expression of Bcl-w and MMP-2 in 100 cases of human gastric carcinoma. Results (1) Among 100 cases of stomach carcinoma, Bcl-w and MMP-2 positive expression rates were respectively 69. 0% , 77. 0% ; (2) The Bcl-w and MMP-2 expression in gastric carcinoma was positively associated with tumor size, invasive depth, histology differentiation and lymph node metastasis(P<0.05) ;(3)The expression of Bcl-w was significantly correlated with MMP-2 in gastric carcinomas (P =0.002) ; (4) Five years survival rates and overall survival of Bclw-positive patients were lower than the Bcl-w -negative patients. Conclusions (1)Bcl-w plays an important role in inhibiting apoptosis of gastric cancer and promoting gastric cancer invasion; (2) Bcl-w-positive expression patients have a bad prognosis and Bcl-w expression in gastric carcinoma can be regarded as a prognosis evaluation index.