Mechanism of SIRT1 acting on tumor formation
- VernacularTitle:沉默信息调节因子1在肿瘤形成中的作用机制
- Author:
Anning FENG
;
Xiangshan FAN
;
Qin HUANG
;
Lihua ZHANG
- Publication Type:Journal Article
- Keywords:
SIRT1;
Deacetylation;
Tumorigenesis
- From:
Journal of Medical Postgraduates
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
SIRT1 is an NAD+-dependent histone deacetylase,involved in many physiological processes,such as cell aging,apoptosis and differentiation.Recent studies have shown that SIRT1 plays a significant role in tumor formation and progression.It deacetylates a wide range of histone and non-histone substrates and regulates gene expression and protein activity that are associated with neoplastic apoptosis and proliferation.
