Dual effects of rapamycin on immuno-suppression and tumor inhibition
- VernacularTitle:雷帕霉素在免疫抑制和肿瘤抑制中的双重作用
- Author:
Ruifang MI
;
Hongbing ZHANG
- Publication Type:Journal Article
- Keywords:
rapamycin;
mTOR;
immuno-suppression;
tumor inhibition
- From:
Basic & Clinical Medicine
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Rapamycin is frequently used as an immunosuppressive agent and also plays an important role in tumor suppression.It combines to FKBP12 and forms a compound to inhibit the serine/threonine protein kinase mammalian target of rapamycin(mTOR),its activation is required for protein synthesis and cell-cycle progression.Rapamycin can block cell cycle at G1 phase and to inhibit cell proliferation.Furthermore rapamycin may inhibit cytokine production and cytokine signaling.Therefore rapamycin is used in the treatment of post-transplantation organ rejection and tumor therapy due to its dual effects of immuno-suppression and tumor inhibition.
