Rapamycin inhibits activation of STAT3 in renal tissue of IgA nephropathy rats
- VernacularTitle:雷帕霉素抑制IgA肾病大鼠肾小球信号蛋白STAT3的活化
- Author:
Zanhua RONG
;
Huijun DUAN
;
Jun HAO
;
Chen WANG
;
Yonghong SHI
- Publication Type:Journal Article
- Keywords:
rapamycin;
IgA nephropathy rat;
p-JAK2;
STAT3;
p-STAT3
- From:
Basic & Clinical Medicine
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of rapamycin on p-JAK2,STAT3,p-STAT3 and PCNA in ranal tissue of IgAN rats.Methods The animal models of IgA nephropathy were devided into control group,IgAN model group,losartan group and rapamycin group.The clinical efficacy of rapamycin,and its influences on the protein and mRNA expressions of STAT3,p-STAT3,p-JAK2 and PCNA were determined by western blot,RT-PCR and immunohistochemical techniques respectively.Results The protein and mRNA expressions of p-STAT3,STAT3,p-JAK2 and PCNA were significantly increased in kidney of IgAN rats(P
