Neuroprotective effects of Topirmate on rats brain with ischemia-reperfusion damage
- VernacularTitle:托吡酯对大鼠脑缺血再灌注损伤的神经保护作用
- Author:
Jingping SHI
;
Jiangbing LIU
;
Xuexu ZHAO
- Publication Type:Journal Article
- Keywords:
cerebral ischemia;
Topirmate;
neuroprotection
- From:
Journal of Clinical Neurology
1992;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the neuroprotective effects of Topiramate (TPM) on rat brain with ischemia-reperfusion damage and its mechanisms.Methods The 30 male SD rats were randomly assigned to sham operated group, ischemia-reperfusion group and TPM treated group.The cerebral ischamia and reperfusion model was made by suture occlusion of right middle cerebral artery(MCAO).Rats in TPM treated group were intraperitoneally injected TPM (80 mg/kg) twice. At 24 h following onset of MCAO,the nerve function score was evaluated with Neurological Grading Scale. The infarction volume was measured with TTC staining. The contents of glutamate (Glu) and gamma-aminobutyric acid (GABA) of cerebral cortex were tested by the high performance liquid chromatography with fluorescent detection. GABAA receptors were observed by immunohistochemistry.Results (1) Compared with the ischemia-reperfusion group, the Neurological Grading Scale of TPM treated group was significantly higher(P
