Effects of advanced glycation end products on peroxisome proliferator activated receptor-? mRNA expression in rat renal cortex
- VernacularTitle:糖基化终末产物对大鼠肾皮质过氧物酶体增殖体激活受体-? mRNA表达的影响
- Author:
Xiaoyan YU
;
Cai LI
;
Chunsheng MIAO
;
Guihua ZHOU
- Publication Type:Journal Article
- Keywords:
diabetic nephropathy;
advanced glycation end products;
peroxisome proliferator-activated receptor-?
- From:
Journal of Jilin University(Medicine Edition)
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of advanced glycation end products(AGEs) on expression of peroxisome proliferator-activated receptor-?(PPAR?) mRNA in rat renal cortex.Methods Normal rats were given tail vein injection with either AGE-modified rat serum protein(AGEs)or AGE-RSP followed by intraperitoneal injection of AG(AGEs+AG)or native rat serum protein(native RSP).Normal rats without any treatment were as controls(Control).PPAR-? mRNA expression was analysed by reverse transcriptase-polymerase chain reaction(RT-PCR).Results PPAR-? mRNA expressed in all rat kidney cortex.There was a decrease for PPAR-? in mRNA levels in the renal cortex of AGEs-treated rats(P
