Epinephrine inhibited AQP1 expression in cultured bovine trabecular meshwork cells
- VernacularTitle:肾上腺素抑制培养牛眼小梁细胞AQP1表达
- Author:
Li ZHAO
;
Fengying KANG
;
Ningli WANG
- Publication Type:Journal Article
- Keywords:
trabecular meshwork cells;
aquaporin;
epinephrine
- From:
Basic & Clinical Medicine
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the mechanism of epinephrine in down-regulating intraocular pressure.Methods The third passage bovine trabecular meshwork cells were divided into control group and epinephrine treated groups in random fashion.Different dosages of epinephrine(10-4、10-5 and 10-6mol/L) were added in cultures and incubated for 14 days.AQP1 expressions was stained by immunocytochemistry method,and the cell area was measured by computer image analytical system.Results The expressions of AQP1 and cell areas in epinephrine treated groups was significantly lower than control group(P
