Effects of soybean isoflavones on cognition and expression of NR2B subtype in hippocampus of Alzheimer's disease rats
- VernacularTitle:大豆异黄酮对Alzheimer病大鼠认知功能及海马NR2B表达的影响
- Author:
Jianzhong BI
;
Ping WANG
;
Shijun WANG
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
soybean isoflavone;
cognition;
NR2B
- From:
Journal of Clinical Neurology
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of soybean isoflavones on cognition and expression of NMDA receptor (NR2B) subtype in hippocampus in Alzheimer's disease (AD) rats induced by amyloid ?-peptide 25-35(A? 25-35).Methods 60 female Wistar rats were randomly divided into five groups: model group, low dose of soybean isoflavone treatment group, high dose of soybean isoflavone treatment group, estrogen group and control group. AD models were made by injection A? 25-35 into bilateral hippocampus and normal saline was used in control group. Different dose of soybean isoflavone and estrogen were administered in soybean isoflavone treatment groups and estrogen treatment group for 18 d, respectively. The praxiology of rats was assessed by Morris water maze and the expression of NR2B in hippocampus was detected by immunohistochemistry method.Results Compared with control group,the learning and memory ability of model group obviously damaged and the expression of NR2B in hippocampus decreased (all P
