EFFECT OF C - PHYCOCYANIN ON GRANULOPOIESIS AND MONOCYTOPOIESIS IN MICE
- VernacularTitle:藻蓝蛋白对小鼠粒单系祖细胞生成的影响
- Author:
Chengwu ZHANG
;
Zhaoqi ZENG
;
Yuanzhen ZHANG
- Publication Type:Journal Article
- Keywords:
Spirulina platensis;
c- phycocyanin;
granulopoiesis and monocytopoiesis;
colony stimulating activity (CSA)
- From:
Chinese Journal of Marine Drugs
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
C - phycocyanin (C - PC) was isolated and purified from blue - green alga Spirulina platensis. By using the thechnique of culture of hemopoietic progenitor cell in vitro, we studied the effect of C -PC on granulopoiesis and monocytopoiesis in mice. The results indicate that C -PC can enhance the proliferation of CFU -GM, promote the granulopoiesis and monocytopoiesis in mice. The C -PC can markedly increase the colony stimulating activity of serum in normal mice. The prepared serum -free spleen cell conditioned media stimulated by C -PC in vivo and in vitro provided the only increase in CFU - GM colony formation. After in -vitro addition of C -PC in the presence of GM -CSF, there was a pronounced increase in the number of CFU -GM colonies.
