The relationship between apelin serum levels and insulin resistance in children with simple obesity
- VernacularTitle:单纯性肥胖儿童血清Apelin水平变化及其与胰岛素抵抗的关系研究
- Author:
Jianguo WANG
- Publication Type:Journal Article
- Keywords:
Simple obesity;
Children;
Apelin;
Insulin resistance;
Pathogencsis
- From:
Journal of Chongqing Medical University
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between Apelin insulin resistance and simple obesity in children.Methods:42 children with simple obesity were enrolled in the study,40 non-obese children as control.All of them were detected for Apelin and insulin resistance(HOMA2-IR).Results:The Apelin in children with simple obesity were higher than those in non-obese children(t=2.483,P = 0.015),and HOMA2-IR hoved the same trends(t = 12.368,P = 0.000 1).Apelin and HOMA2-IR also have positive correlation with BMI,the correlation coefficient r was 0.768(t = 6.253,P = 0.000 1)and 0.754(t = 5.641,P = 0.004),each.Apelin and HOMA2-IR were also independent factors associated with children simple obesity,OR was 1.416(P=0.017)and 1.394(P=0.028),respectively.Conclusions:Increased Apelin level in children with simple obesity may associated with insulin resistance.
