Expression and significance of bcl-2 and vascular endothelial growth factor in nephroblastoma
- VernacularTitle:血管内皮生长因子和bcl-2在肾母细胞瘤中的表达及意义
- Author:
Jian CHEN
- Publication Type:Journal Article
- Keywords:
Nephroblastoma;
B-cell lymphoma/leuke mia-2(bcl-2);
Vascular endothelial growth factor
- From:Journal of Chongqing Medical University
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the expression of vascular endothelial growth factor(VEGF)and B-cell lymphoma/leuke mia-2(bcl-2) in nephroblastoma and to evaluate the relationship between VEGF and bcl-2.Methods:With mouse anti-human VEGF and bcl-2 monoclonal antibody,immunohistochemistry was used to examine 6)the expression of VEGF protein and bcl-2 protein in 17 cases of nephroblastoma and 7 cases of normal tissue as contrast.VEGF mRNA and bcl-2 mRNA expression was examined by in situ hybridization.Results:The positive expressions of bcl-2 protein in nephroblastoma(82.4%)were significantly higher than those in normal tissues(28.5%).The positive expressions of VEGF protein in nephroblastoma(58.8%)were significantly higher than those in normal tissues(14.3%).The rate of bcl-2,VEGF mRNA in nephroblastoma was 88.2%,82.4%,respectively.The expression of bcl-2,VEGF mRNA was increased significantly in nephroblastoma compare with control.VEGF expression and bcl-2 in nephroblastoma were positively related(rs=0.633,P
