Effect of Glycyrrhizin on Heptitis B Virus Infection in HepG2.2.15 Cell Line
- VernacularTitle:甘草甜素对HepG2.2.15细胞株HBV感染的影响
- Author:
Yongwei LI
;
Yunwei GUO
;
Gang LI
- Publication Type:Journal Article
- Keywords:
glycyrrhizin;
hepatitis B virus;
HepG2.2.15 cell line
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of glycyrrhizin(GL) on the expression of hepatitis B virus e antigen(HBeAg),hepatitis B virus surface antigen(HBsAg),HBV DNA levels and cell proliferation in HepG2.2.15 cell line.Methods HBV DNA level was examined by Real-time PCR.HBsAg and HBeAg levels were examined by ELASA,and cell proliferation was examined by MTT before and after stimulated with GL.The GL groups were compared with the blank control group.Results HBsAg levels in the GL groups were inhibited in dose-dependent manner compared with the blank control group(P
