Intervention Effect of Berberine on the Level of Serum IL-1?, Hs-CRP, Monocytes Infilitrating and the Expression of HSP-70 in Diet-induced Hyperlipidemic and Cpn-infected Mice
- VernacularTitle:黄连素对模型小鼠血清IL-1?、Hs-CRP、内膜下单核细胞浸润及热休克蛋白染色的干预作用
- Author:
Song WANG
;
Wei WU
;
Yude LIU
- Publication Type:Journal Article
- Keywords:
atherosclerosis;
Chlamydia pneumoniae;
berberine;
IL-1?;
Hs-CRP;
HSP-70;
mice
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the variation of serum IL-1?, Hs-CRP, the monocytes infilitrating into the intima, the expression of HSP-70 in diet-induced hyperlipidemic and chronic Cpn-infected mice and the intervention of berberine. Methods Mice were inoculated intranasally with Cpn three times, every 2 weeks over a 6-week period and fed with high cholesterol diet. C57BL/6J mice were divided randomly into 6 groups:Ber1 group, Ber2 group, azithromycin group, atorvastain group, model group, and normal group. Ber1 group were given berberine at the beginning of Cpn infecting, while Ber2 group, azithromycin group and atorvastain group were given the drug after the 3rd Cpn infecting. The serum index, HE dye of the aortas and immune-histochemistry index were observed. Results The level of serum IL-1?, Hs-CRP, the monocytes infilitrating counting and the expression of HSP-70 in model group were increased. All of the index in Ber group, azithromycin group and atorvastain group declined to some extent. Conclusions Berberine has effect of decreasing inflammatory indexes of diet-induced hyperlipidemic and chronic Cpn-infected mice.
