Expression and clinical significance of Bmi-1,Caspase-8 protein in primary epithelia ovarian cancer
- VernacularTitle:Bmi-1、Caspase-8蛋白在原发上皮性卵巢癌中的表达及其临床意义
- Author:
Chunhua LIU
- Publication Type:Journal Article
- Keywords:
Bmi-1 protein;
Caspase-8 protein;
Ovarian cancer;
Immunohistochemistry
- From:
Journal of Chongqing Medical University
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the relationship between Bmi-1,Caspase-8 protein expression and carcinogenesis、progression and recurrence of ovarian cancer.Methods:A specific and sensitive immunohistochemical SABC assay was used to detect the expression of Bmi-1,Caspase-8 in paraffin-embedded sections of 60 cases of primary epithelia ovarian cancer,16 cases of epithelial benign ovarian tumors,and 10 cases of normal ovarian tissues individual.Results:The positive expressions of Bmi-1 in epithelial ovarian cancers(68.3%) were significantly higher than those in normal tissues(37.5%) and benign ovarian tumors(10.0%) The positive expressions of Caspase-8 in epithelial ovarian cancers(31.7%) were significantly lower than those in normal tissues(68.8%) and benign ovarian tumors(90.0%).It showed the tendency that the expression of Bmi-1 increased and Caspase-8 decrease of the histological differentiation(P
